2/15/2024 0 Comments Cyanokit hydroxocobalamin![]() Pediatric cyanide poisoning: Causes, manifestations, management, and unmet needs. 67135 - Geller RJ, Barthold C, Saiers JA, et al. 67134 - Cyanokit (hydroxocobalamin) European product information. Psychomotor development following early treatment of severe infantile vitamin B12 deficiency and West syndrome - Is everything fine? A case report and review of literature. 62570 - Glaser K, Girschick HJ, Schropp C, et al. Vitamin B12 deficiency with intrinsic factor antibodies in an infant with poor growth and developmental delay. 60942 - McNeil K, Chowdhury D, Penney L, et al. Neuroregression as an initial manifestation in a toddler with acquired pernicious anemia. 60941 - Yoganathan S, Thomas MM, Mathai S, et al. Isolated cerebellar involvement in vitamin B12 deficiency: A case report. 60939 - Chakrabarty B, Dubey R, Gulati S, et al. Solid food refusal as the presenting sign of vitamin B12 deficiency in a breastfed infant. 60937 - Ide E, Van Biervliet S, Thijs J, et al. Vitamin B12 deficiency in children and adolescents. 60930 - Rasmussen SA, Fernhoff PM, Scanlon KS. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Vitamin B12 deficiency presenting as acute ataxia. Severe pernicious anaemia in an 8-year-old African girl. 60926 - van Loon M, Postels DG, Heikens GT, et al. Long term follow up of patients with transcobalamin II deficiency. Early diagnosis and treatment of cobalamin deficiency of infancy owing to occult maternal pernicious anemia. 60924 - Banka S, Roberts R, Plews D, et al. Vitamin B12 deficiency in infants secondary to maternal causes. Oral Versus Intramuscular Cobalamin Treatment in Megaloblastic Anemia: A Single-Center, Prospective, Randomized, Open-Label Study. 43997 - Bolaman Z, Kadikoylu G, Yukselen V, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. 43996 - Andres E, Loukili NH, Noel E, et al. Neuropsychiatric disturbances in presumed late-onset cobalamin-C disease. 33669 - Roze E, Gervais D, DemeretS, et al. ![]() Therapeutic approaches to cobalamin-C methylmalonic academia and homocystinuria. 33668 - Bartholomew DW, Batshaw ML, Allen RH, et al. Remethylation defects: guidelines for clinical diagnosis and treatment. 33667 - Ogier de Baulny H, Gerard M, Saudubray JM, et al. Long-term outcome in treated combined methylmalonic academia and homocystinemia. 33666 - Andersson HC, Marble M, Shapira E. 33665 - Hydroxocobalamin injection package insert. West Conshohocken, PA: BTG International, Inc. † Off-label indication Revision Date:, 01:56:53 PM References 33229 - Cyanokit (hydroxocobalamin) package insert. Specific guidelines are not available it appears that no dosage adjustments are needed. Specific guidelines for dosage adjustments in renal impairment are not available it appears that no dosage adjustments are needed. In studies, oxalate crystals have been found in the urine of both healthy patients and those being treated for cyanide poisoning. Hydroxocobalamin and cyanocobalamin are excreted unchanged in the urine. Specific guidelines for dosage adjustments in hepatic impairment are not available it appears that no dosage adjustments are needed. Therapeutic Drug Monitoring Maximum Dosage Limitsģ0 mcg/day IM, followed by 200 mcg/month IM is FDA-approved maximum however, doses up to 2,000 mcg/day IM are used off-label 10 g IV (total dose) for cyanide poisoning.ġ00 mcg/day IM, followed by 50 mcg/month IM is FDA-approved maximum however, doses up to 2,000 mcg/day IM are used off-label 140 mg/kg (Max: 10 g) IV total dose has been used off-label for cyanide poisoning. 1,000 mcg IM once is the flushing dose for Schilling test/vitamin B12 absorption test.
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